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KMID : 1134820090380081003
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 8 p.1003 ~ p.1007
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Effects of Thiosulfinates Isolated from Allium tuberosum L. on the Growth of Human Cancer Cells
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Park Sun-Young
Seo Kwon-Il
Park Kyung-wuk
Kang Kap-Suk
Kim Jae-Yong
Park Ki-Hun
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Abstract
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To develop Allium tuberosum L. as a cancer preventive food material, thiosulfinates and biological active components were isolated from Allium tuberosum L. and the apoptotic effects of thiosulfinates in human cancer cells were examined. Thiosulfinates decreased viable cell numbers in dose- and time-dependent manners. Thiosulfinates at the 20 ㎍/mL concentration inhibited more than 60% cell proliferation in HepG2 and A549 human cancer cells, respectively. Also the morphology of cells treated with thiosulfinates of 30 ㎍/mL concentration was distorted with shrunken cell mass while the cell number was lower than that of control cells. The IC?? values in the HepG2 cells were higher than those of the A549 cells. Thiosulfinates at the 30 ㎍/mL concentration showed the formation of apoptotic bodies and a nuclear condensation, and an increase in the cell populations of the sub-G1 phase in the HepG2 cells. These results indicate that thiosulfinates from Allium tuberosum L. inhibited cell proliferation in HepG2 via apoptosis.
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KEYWORD
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Allium tuberosum L., thiosulfinates, cytotoxic activity, apoptosis
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